Warfarin ketoprofen interactions
Samuzshura/ October 2, 2012/ Tylenol & Acetaminophen
It may harm them. The recommended starting dose of Ketoprofen capsules in otherwise healthy patients is 75 mg three times or 50 mg four times a day.
Pharmacoepidemiol Drug Saf in press. Rheumatoid Arthritis HumirahydroxychloroquinePlaquenilsulfasalazineleflunomideEnbrelMore Back Pain tramadolnaproxenCymbaltaaspirinibuprofenMore Interaction between diflunisal and warfarin. NSAIDs inhibit platelet aggregation and have been shown to prolong bleeding time in some patients. In some of these studies there were more dropouts due to gastrointestinal side effects among patients on Ketoprofen than among patients on other NSAIDs.
Bleeding from a number of sites may be a complication of warfarin treatment and GI bleeding a complication of Ketoprofen treatment. If Ketoprofen capsules are used in patients with a recent MI, monitor patients for signs of cardiac ischemia.
Drug Saf ; 7: Plasma half-lives, plasma metabolites and anticoagulant efficacies of the enantiomers of warfarin in man.
Ketoprofen - Clinical Pharmacology
Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Prolongation of prothrombin time and severe gastrointestinal bleeding associated with combined use of warfarin and ketoprofen. To attempt to minimize these effects, physicians may wish to prescribe that Ketoprofen capsules be taken with antacids, food, or milk. Therefore, it can prolong bleeding time by approximately 3 to 4 minutes from baseline values. Warfarin metabolism and drug—drug interactions.
However, its mode of action, like that of other non-steroidal anti-inflammatory drugs, is not fully understood. Ketoprofen Capsules USP 50 mg.
In this same cohort, the. Sulindac, prothrombin time, and anticoagulants. Abnormal spermatogenesis or inhibition of spermatogenesis developed in rats and dogs at high doses, and a decrease in the weight of the testes occurred in dogs and baboons at high doses. Comparison of bleeding complications of warfarin and warfarin plus acetylsalicylic acid: Ketoprofen and other non-steroidal anti-inflammatory drugs cause nephritis in mice and rats associated with chronic administration.
Rare cases of interstitial nephritis or nephrotic syndrome have been reported in humans with Ketoprofen since it has been marketed. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. We comply with the HONcode standard for trustworthy health information - verify here.
NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices.
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