Celecoxib and cardiovascular disease
Samujas/ October 2, 2012/ Eye Care
Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Hans Bastian, Andreas Krause. Use of first and second generation cyclooxygenaseselective nonsteroidal antiinflammatory drugs and risk of acute myocardial infarction.
Cardiovascular outcomes in new users of coxibs and nonsteroidal antiinflamatory drugs: The results of this study generated a lot of discussion, including the proposal that the results were evidence that the imbalance on prostacyclin and thromboxane formation that resulted from COX-2 specific inhibition, predisposed patients to adverse cardiovascular events. People with chronic conditions such as rheumatoid arthritis, obesity or diabetes already face higher odds of developing heart problems, as do those with existing risk factors such as high blood pressure and high cholesterol and a strong family history of heart disease.
Pharmacotherapy Principles and Practice.
Current evidence suggests that naproxen, a nonselective NSAID, is associated with the lowest risk of cardiovascular events. The intention-to-treat data analyses were truncated at 30 months, and the on-treatment analyses were truncated at 43 months.
All the participants also received Nexium esomeprazolea drug that reduces stomach acid, for "gastric protection.
This arose initially because of reports of adverse effects of rofecoxib, but the concern spread to include other selective COX-2 inhibitors as it was thought that the problem may have been a class effect related to a potential pro-thrombotic state induced by unopposed COX-2 inhibition. It caused as many asheart attacks in the U. The publication is also useful to pharmacy technicians, students, other health professionals and individuals interested in health management.
It can be concluded from the CLASS study that over a period of approximately 9 months the risk of adverse cardiovascular events on celecoxib therapy appears to be similar to that which occurs during therapy with two commonly used NSAIDS, with the exception of stroke which appeared to be more common in patients receiving NSAIDs. Addiction to opiates is possible, liver damage, constipation chronicallyimpaired mental state,etc.
Back inthe FDA warned that taking nonsteroidal anti-inflammatory drugs NSAIDs like ibuprofen and naproxen increased the risk of having a heart attack or stroke. Though the main purpose of the study was to see whether celecoxib raised the risk of heart problems in this group of patients, Nissen and his colleagues also assessed whether all or any of the three drugs were associated with serious gastrointestinal upset, kidney complications or death.
Compared to Articles in Other Medical Journals. Celecoxib for rheumatoid arthritis. While there appear to be differences between individual drugs in the risk of producing serious cardiovascular events, this does not appear to be clearly related to the degree of COX-2 selectivity.
Some Americans are also allergic to aspirin.
Most nonsteroidal anti-inflammatory drugs increase risk of cardiovascular events and stroke.
A nationwide population-based cohort study. International Journal of Molecular Sciences Heart, Lung and Circulation We also included a broader outcome — major adverse cardiovascular events — as a secondary composite outcome to provide greater power to detect differences among the three treatments. Some research shows that it can also slow cancer development and increase appetite. After about 18 months of therapy a statistically significant difference in cardiovascular events was found between the patients receiving rofecoxib and those receiving placebo Figure 1.
Naproxen therapy may be associated with an increased risk of stroke.
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