What is normal dosage of dilantin
Akijar/ October 2, 2012/ Clearance & Specials
Every effort has been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made to that effect. OR Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription. The patient should be advised that, because these signs and symptoms may signal a serious reaction, they should report any occurrence immediately to a physician even if mild or when occurring after extended use.
In all cases of lymphadenopathy, follow-up observation for an extended period is indicated and every effort should be made to achieve seizure control using alternative antiepileptic drugs.
Usual Adult Dose for Seizures
Phenytoin sodium is related to the barbiturates in chemical structure, but has a five-membered ring. Dermatological manifestations sometimes accompanied by fever have included scarlatiniform or morbilliform rashes. Appropriate diagnostic procedures should be performed as indicated.
NDC Dilantin ready-mixed solution containing 50 mg phenytoin sodium per milliliter is supplied in 5-mL Steri-Vials. Prior to the administration, the patency of the IV catheter should be tested with a flush of sterile saline.
It is essential to take phenytoin exactly as directed by your doctor.
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Because of the increased risk of adverse cardiovascular reactions associated with rapid administration, intravenous administration should not exceed 50 mg per minute in adults. Phenytoin may also raise the serum glucose level in diabetic patients. When a change in the dosage form or brand is prescribed, careful monitoring of phenytoin serum levels should be carried out. The most common adverse reactions encountered with phenytoin therapy are nervous system reactions and are usually dose-related.
Serum concentrations should be monitored and care should be taken when switching a patient from the sodium salt to the free acid form. Trough levels provide information about clinically effective serum level range and confirm patient compliance and are obtained just prior to the patient's next scheduled dose.
If the rash is exfoliative, purpuric, or bullous or if lupus erythematosus, Stevens-Johnson syndrome, or toxic epidermal necrolysis is suspected, use of this drug should not be resumed and alternative therapy should be considered. The information at Drugs. Slow metabolism may be due to limited enzyme availability and lack of induction; it appears to be genetically determined.
In view of isolated reports associating phenytoin with exacerbation of porphyria, caution should be exercised in using this medication in patients suffering from this disease. I take mg. Phenytoin is contraindicated in those patients who are hypersensitive to phenytoin or other hydantoins.
Phenytoin was negative in the Ames test and in the in vitro clastogenicity assay in Chinese hamster ovary CHO cells.
However, cardiac events have also been reported in adults and children without underlying cardiac disease or comorbidities and at recommended doses and infusion rates. Urinary excretion of phenytoin and its metabolites occurs partly with glomerular filtration but more importantly by tubular secretion.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution or container permit. Because the fraction of unbound phenytoin is increased in patients with renal or hepatic disease, or in those with hypoalbuminemia, the monitoring of phenytoin serum levels should be based on the unbound fraction in those patients [see Warnings and Precautions 5.
Drug interactions resulting in decreased effectiveness of nondepolarizing neuromuscular blocking agents have been reported. A faint yellow coloration may develop, however this has no effect on the potency of the solution.
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