Depakote high ammonia level

Tojalmaran/ October 2, 2012/ Allergy & Health Alert Aids

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Here's another case actually, this one is mostly valproic acid toxicity on Erik Mattison's blog. The pathogenesis of hyperammonemic encephalopathy remains unclear. The symptoms of delirium resolved slowly during the 96 hours following the discontinuation of divalproex sodium.

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National Center for Biotechnology InformationU. Literature review current through: Long term depakote use is directly linked to dangerous levels of ammonia. Women who are pregnant must not take Depakote to prevent migraine headaches. Newer Post Older Post Home.

Valproic acid is a broad-spectrum antiepileptic drug that is approved for the treatment of several types of seizures.

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These include supplementation with carnitine, lactulose, or neomycin and protein restriction [ 3 ]. View at Google Scholar C.

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My family doctor was informed and he did a 2nd test that was even higher. To date, there are only four reported cases of hyperammonemia in the elderly in the medical literature [ 4111242 ].

Ativan, Benadryl failed to resolve behavioral emergency. Comment Vote up Report. Changes in mental status are thought to be due to high levels of ammonia and the presence of other organic acids.

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Raja and Azzoni assessed adult patients admitted to a psychiatric unit receiving a mood stabilizer such as VPA and found that The risk factors for the development of valproic acid-induced hyperammonemia include higher doses of the medication, concomitant use of other antilepiliptics like topiramate, carnitine deficiency, and the presence of congenital abnormalities of urea cycle [ 512222443 ].

Serum lithium was 1.

Valproic Acid Induced Hyperammonemia in a Long Time Treated Patient

Get helpful advice on your cases from a community of physicians. My son started out with mild autism Academically. I passed out several times per day and had a mystery illness. It is important to ensure that serum ammonia levels are accurately measured as faulty storage and transport can lead to hemolysis and erroneous elevations in serum ammonia level [ 13 ]. A poster above queried how a manufacturer could create a drug with potentially lethal consequences albeit rare.

Taking Depakote with certain other medicines, even for a short period of time, can cause side effects or affect how well they work. This is patients second time on depakote. A summary table to facilitate the emergency management of VPA overdose is provided table 1.

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