Atorvastatin hplc analysis

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The results obtained by the proposed method were close to the label claim of both the drugs Table 2. The proposed method was statistically evaluated and can be applied in regular quality control of AT, EZ and FE in pharmaceutical dosage forms.

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System suitability is an integral part of the method development and is used to ensure adequate performance of chromatographic system. Visit for more related articles at Pharmaceutical Regulatory Affairs: The resultant responses to the variations were statistically compared with the proposed method. Satisfactory results were obtained from the validation of the method.

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A deliberate variations in the separation parameters i. Best resolution has been determined using a Luna C 18 column with acetonitrile—ammonium acetate buffer pH 4-tetrahydrofuran THF as mobile phase. Decisively after several experimental trials, the best result was obtained by use of The suitable wavelength considered for monitoring the drugs was nm.

The obtained chromatograms of the mixture sample indicate that separation of all the analytes was successful. A fixed amount of pre-analyzed sample was taken and standard drug was added at three different concentrations. Schroff, Head of the Department of Pharmaceutics. Peer review under responsibility of King Saud University. Abstract A simple, specific and accurate reverse phase liquid chromatographic method was developed for the simultaneous determination of Atorvastatin calcium and Nicotinic acid in tablet dosage forms.

The method was validated according to ICH guidelines. The typical chromatogram at the optimum condition is depicted in Figure 2.

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Accuracy was determined by analyzing a known concentration of drug, viz. The authors are grateful to Dr.

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The effluent was monitored at nm. Figure 1 presents the chemical structures of the three antihyperlipidemic agents used for HPLC study.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In contrast to monotherapy where both EZ and FE each provide only modest effect, the combined therapy produces significantly greater reductions in LDL-C.

HPLC grade acetonitrile, methanol E. The resulted overlaid chromatograms from the robustness study are shown in Figure 5. Gandhi, Principal, Anand Pharmacy College, Anand, for providing necessary facilities and encouragement.

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About the Journal The Indian Journal of Pharmacy was started in as "a quarterly journal devoted to the Science and practice of Pharmacy in all its branches". This enzyme catalyses the conversion of HMG-Co A to mevalonate, an early and rate-limiting step in cholesterol biosynthesis [ 12 ].