Azithromycin for legionnaires disease

Nalmaran/ October 2, 2012/ Aleve & Naproxen

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Patients were recruited during a month period at 13 health care centers in the United States and Canada. An older fluoroquinolone, ciprofloxacin, does inhibit CYP3A4. The mortality of community-acquired Legionnaires' disease ranges from 16 to 30 percent if untreated or treated with inactive antibiotics; the mortality for nosocomial Legionnaires' disease can approach 50 percent given the underlying illness of the patient [ 1 ].

Twenty-five hospitalized patients with community-acquired pneumonia and a positive result of a L.

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For patients with severe disease or immunocompromise, prolonged courses may be required. Twenty-three of 25 patients enrolled in the study were clinically evaluable at the primary end point of the study, 4—6 weeks after therapy.

Clinical response was judged to be nonevaluable when the patient's response could not be assessed for any reason, including missed visit, receipt of intervening antibacterial therapy, or receipt of insufficient therapy i.

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The reported rank order of in vitro and intracellular activity against L pneumophila is quinolones, then ketolides, and then macrolides [ 34 ]. Most events were mild to moderate in severity and were not judged to be related to treatment.

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Sign In or Create an Account. Resident, Fellow or Student. The infiltrates were considered to be patchy in 7 patients and diffuse in 5 patients. If other drugs are used, the duration should be weeks.

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Clinical efficacy of intravenous followed by oral azithromycin monotherapy in hospitalized patients with community-acquired pneumonia. Twenty-five hospitalized patients with community-acquired pneumonia and a positive result of a L. The patient had stayed in a French hotel for 1 week, until 2 days before admission.

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The patient responded well to alternative effective antimicrobial therapy. In vitro activity of azithromycin against clinical isolates of Legionella species. Imaging of cavitary necrosis in complicated childhood pneumonia.

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Wolf J, Daley AJ. Single dose azithromycin for the treatment of Haemophilus ducreyi skin ulcers in Papua New Guinea. To continue reading this article, you must log in with your personal, hospital, or group practice subscription.

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Respiratory specimens were cultured locally for routine pathogens and Legionella species. Consultations See the list below: Reevaluation of the definition of Legionnaires' disease: One patient died of a myocardial infarction on the second hospital day.